Dr. Amy Lane, Ph.D.      Center for Marine Biotechnology and Biomedicine      Scripps Institution of Oceanography, UCSD      9500 Gilman Drive, Mail Code 0204      La Jolla, CA 92093-0204      email: AmyLane@ucsd.edu      Phone: (858) 822 - 6652

Bio

Amy Lane graduated summa cum laude with a B.S. in Chemistry from Indiana State University in 2003.  Her path then turned southward to Atlanta for graduate school at Georgia Institute of Technology.  There, Amy studied under Dr. Julia Kubanek, exploring the ecological roles and drug discovery potential of natural products from macroalgae and freshwater plants.  Amy earned her Ph.D. in Chemistry at Georgia Tech in 2008, and then joined the Moore lab as an NIH IRACDA postdoctoral fellow.  Amy is now exploring the biosynthesis of natural products by marine actinomycetes, with a particular interest in production of DNA-interfering molecules by Salinispora spp.  As part of the NIH IRACDA fellowship program, Amy is also pursuing teaching activities at San Diego State University.

Publications

Lane AL, Nyadong L, Galhena AS, Shearer TL, Stout EP, Parry RM, Kwasnik M, Wang M, Hay ME, Fernandez FM, Kubanek J.  (2009) Desorption electrospray ionization mass spectrometry reveals surface-mediated antifungal chemical defense of a tropical seaweed.  Proceedings of the National Academy of Sciences.  106: 7314-7319.

Cover feature:  “Seaweed employs distributed chemical defense.” http://www.pnas.org/content/106/18/7265#sec-7

Commentary: http://www.pnas.org/content/106/18/7269.extract

Nyadong L, Hohenstein EG, Galhena AS, Lane AL, Kubanek J, Sherrill CD, Fernandez FM.  (2009) Reactive desorption electrospray ionization mass spectrometry (DESI MS) of natural products of a marine alga.  Analytical and Bioanalytical Chemistry.  394: 245-254

Lane AL,* Stout EP,* Lin AS, Prudhomme J, Le Roche K, Fairchild CR, Franzblau SG, Hay ME, Aalbersberg W, Kubanek J.  (2009) Antimalarial Bromophycolides J-Q from the Fijian Red Alga Callophycus serratus.  Journal of Organic Chemistry.  74: 2736-2742. 

Stout EP, Hasemeyer A, Lane AL, Davenport T, Engel S, Hay ME, Fairchild CR, Prudhomme J, Le Roche K, Aalbersberg W, Kubanek J. (2009) Antibacterial neurymenolides from the Fijian red alga Neurymenia fraxinifolia. Organic Letters.  11: 225-228.

Lane AL, Kubanek J.  (2008)  Secondary metabolite defenses against pathogens and biofoulers.  Invited review.  In Algal Chemical Ecology.  C.D. Amsler, Ed.  Springer-Verlag.  pp. 229-243.

Jiang RW, Lane AL, Mylacraine L, Hardcastle KI, Fairchild CR, Aalbersberg W, Hay ME, Kubanek J.  (2008) Structures and absolute configurations of sulfate-conjugated triterpenoids including an antifungal chemical defense of the green macroalga Tydemania expeditionis.  Journal of Natural Products. 71: 1616-1619. 

Lane AL, Stout EP, Hay ME, Prusak AC, Hardcastle K, Fairchild CR, Aalbersberg W, Kubanek J. (2007) Callophycoic acids and callophycols from the Fijian red alga Callophycus serratus.  Journal of Organic Chemistry.  72: 7343-7351.

Lane AL, Kubanek J. (2006) Structure-activity relationship of chemical defenses from the freshwater plant Micranthemum umbrosum.  Phytochemistry.  67: 1224-1231. 

Kolodny NH, Bauer D, Bryce K, Klucevsek K, Lane A, Medeiros L, Mercer W, Moin S, Park D, Peterson J, Wright J, Yuen C, Wolfson AJ, Allen MM.  (2006) Effect of nitrogen source on cyanophycin synthesis in Synechocystis sp. strain PCC 6308.  Journal of Bacteriology. 188: 934-940.

*denotes authors contributed equally to this work.  

Selected Presentations

Lane AL, Kubanek J. (2008)  Invited “oral poster.”  Antifungal chemical defenses of the Fijian red alga Callophycus serratus.  Gordon Conference on Marine Natural Products.  Ventura, CA. 

Lane AL, Kubanek J. (2007)  Poster. Algae compete against scleractinian corals using allelopathy.  Benthic Ecology Meeting. Atlanta, GA.

Lane AL, Kubanek J. (2006)  Poster.  Novel antitumor diterpene benzoates from the Fijian Red Alga Callophycus serratus.  ACS National Meeting.  Atlanta, GA.

Lane AL, Glendening E, Allen JM, Allen SK.  (2003) Poster. Photoallergens: They don’t just irritate your skin.  ACS National Meeting.  New Orleans, LA. 

Honors

2008-present            NIH IRACDA postdoctoral fellowship (UCSD)

2007-2008               MacArthur foundation Sam Nunn fellowship (Georgia Tech)

2004-2008               NSF-IGERT aquatic chemical signaling fellowship (Georgia Tech)

2004-2005               GAANN drug design and discovery fellowship (Georgia Tech)

2003-2008               Presidential fellowship (Georgia Tech)